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Product name
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Carmustin
|
|
Molecular Formula
|
C5H9Cl2N3O2
|
|
Molecular Weight
|
214.05
|
|
CAS No.
|
154-93-8
|
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Quality Standard
|
96.0-101.0%
up, medical grade
|
|
Appearance
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White powder
|
|
TEST ITEMS
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SPECIFICATIONS
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RESULTS
|
|
Characteristics
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A YELLOWISH CRYSTALS, OR CRYSTALLINE
POWDER. ODOURLESS, VERY SLIGHTLY SOLUBLE IN WATER, FREELY SOLUBLE IN ETHANOL.
|
Conforms
|
|
Identification
|
1.POSITIVE
2.POSITIVE
3, MAXIMUM ABSORPTION AT THE
WAVELENGTH OF 230NM
|
Conforms
|
|
MELTING RANGE
|
30℃-32℃, MELTS WITH DECOMPOSITION
|
30.7℃-31.7℃, MELTS WITH DECOMPOSITION
|
|
LOSS ON DRYING
|
≤0.5%
|
0.36%
|
|
CLARITY OF SOLUTION
|
CLEAR
|
CONROMS 0.1 %
|
|
COLOR OF SOLUTION
|
< YG5
|
< YG5
|
|
RESIDUE SOLVENTS
1, DMF
2,EHTANOL
3,ISOPROPYL ALCOHOL
|
0.088% MAX
0.5% MAX
0.5% MAX
|
< 0.088%
< 0.5%
< 0.5%
|
|
RELATED SUBSTANCE
|
3.0% MAX
|
0.62%
|
|
INDIVIDUAL IMPURITY
|
1.5% MAX
|
0.16%
|
|
RESIDUE ON IGNITION
|
0.1% MAX
|
0.03%
|
|
HEAVY METALS
|
20PPM MAX
|
|
|
Assay(BY UV)
|
96.0% - 101.0%, CALCULATED BASED ON
DRIED SUBSTANCE
|
99.68%
|
Function of Carmustine
Carmustine is a nitrosourea
alkylating agent. Although it has a chloroethyl group in its structure, its
chemical reaction is different from that of nitrogen mustard. Because it can
penetrate the blood-brain barrier, it is often used for brain tumors and intracranial
metastases.
It is now believed that this product
forms isocyanate and diazonium hydroxide through the action of OH- ions under
physiological conditions after entering the body. Isocyanates carbamylate
proteins, and diazonium hydroxide generates carbanion ions to alkylate
biological macromolecules. Isocyanate can inhibit DNA polymerase, inhibit DNA
repair and RNA synthesis. This product is a periodic non-specific drug, and it
is not completely cross-resistant with general alkylating agents. The resistance
of nitrite drugs has little to do with multi-drug resistance genes. This
product has high fat solubility. Permeable to the blood-brain barrier, the
concentration in cerebrospinal fluid is 50% to 70% of the plasma concentration.
It is mainly metabolized in the liver. The metabolites stay in the plasma for
several days and still have anticancer effects. They are slowly released after
binding to the protein and have a lasting effect.
