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Product name
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Echinacea Purpurea Extract ; Echinacea Extract
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Specification
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Phenols ≥ 4%
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Loss on drying
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≤5.0%
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Extraction solvent
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Ethanol &
water
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Pesticide Residue
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Complies
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Quality Standard
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USP42
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COA of Echinacea Purpurea Extract
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Items
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Specification
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Results
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Appearance
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Yellow-green to deep yellow-green powder
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Yellow-green powder
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Identification
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The retention time of the major peak in the sample
solution corresponds to that of the chicoric acid peak in standard solution
A, and the second mostprominent peak corresponds to that of the caftaric
acid peak in standard solution B.
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Complies
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Loss on drying
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Not more than 5.0%
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3.8%
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Elemental impurities
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Arsenic not more than 1.0µg/g
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--
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Cadmium not more than 0.5µg/g
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--
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Lead not more than 5.0µg/g
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--
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Mercury not more than 1.0µg/g
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--
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Pesticide residue
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Complies
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--
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Residual solvents
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Ethanol should not more than 5000 ppm
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--
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Microbial limit test(MLT)
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Total bacteria not more than 10000 cfu/g
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Complies
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Total yeasts and moulds not more than 1000 cfu/g
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Complies
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Escherichia coli. and salmonella absent
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Complies
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Assay
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Contains Phenols(calculated as the total of caftaric
acid, chicoric acid and chlorogenic acid) should not less than 4.0%,
calculated on the anhydrous substance.
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7.2%
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Conclusion
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The above materials are done based on USP42 and all the
testing data meet the established specification.
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Echinacea's main active ingredients, polyphenols, caffeic acid derivatives
and polysaccharides have the following function -- Significantly improve immune
system:
·
Antibiotics
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Activation of tissue growth
·
Blood purification
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Antiviral effect
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Anti-oxidation and anti-free radical effect
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Tumor inhibition
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Inhibiting effect on hyaluronidase
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Anti-inflammatory effect
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Interferon-like effect
1. Immune stimulation
Inulin: plays a role by increasing the
number of granulocytes and white blood cells, and increases the chemotaxis of
monocytes and neutrophils.
Polysaccharide: the hydrocarbon
receptors on the surface of T lymphocytes and macrophages produce immune
stimulation, which can increase the phagocytosis ability of macrophages, and
stimulate macrophages to increase the number of tumor necrosis factor,
interferon, and white blood cell intermediation, which can destroy tumor cells.
Alkylamines and caffeic acid
derivatives: lipophilic alkylamines can increase the phagocytic ability of
macrophages.
Echinacea: increases the activity of
non-specific T cells, produces interferon, promotes the secretion of
lymphocytes, reduces t-helper cells, and reduces the ratio of t-helper cells to
inhibitory factors.
2. Tissue renewal and anti-infection effect
Inhibiting hyaluronidase (hyaluronidase)
can stimulate the growth of fibroblasts and the synthesis of glucosaminase,
produce corticosterone and promote the secretion of adrenal cortical
hormone.Polysaccharides have anti-infection effects.
3. Antibacterial effect
Echinacea and caffeic acid derivatives
have weak antibacterial activity.
4. Antiviral effect
Can inhibit influenza, herpes and
blistering viruses, antiviral activity is attributed to the inhibition of
hyaluronidase, can block the cell surface of the virus receptor.
