Buy best GW501516 from ANDSON BIOLOGICALTECH. CO.,LTD
Name:GW501516
Formula:C21H18F3NO3S2
Molar mass :453.498 g/mol g·mol−1
CAS :317318-70-0
InChI Key : YDBLKRPLXZNVNB-UHFFFAOYSA-N
Assay : ≥98% (HPLC)
Form : powder
Color : white to beige
Solubility: DMSO: 20 mg/mL, clear
Storage temp: −20°C
Biochem/physiol Actions
GW501516 is a selective Peroxisome Proliferator-Activated Receptor delta (PPARδ) agonist with high affinity (Ki = 1 nM) and potency (EC50 = 1 nM) for PPARδ and > 1000 fold selectivity over PPARα and PPARγ. GW501516 was shown to activate some of the same pathways activated through exercise, and was investigated as a potential treatment for obesity, diabetes, dyslipidemia and cardiovascular disease. However, GW501516 also showed an increase in cancer in rats.
PPARδ activation by GW501516, retards weight gain through fatty acid catabolism in adipose tissue and skeletal muscles.GW501516 causes an increase in the levels high-density lipoprotein cholesterol and apolipoprotein A (apoA) and reduction in the low density-lipoprotein cholesterol, apoB, and triglyceride.
