Product name: L-Glutathione oxidized
Synonyms: GSSG
INCI name: oxidized Glutathione
CAS No.: 27025-41-8
EINECS: 248-170-7
Quality: assay 98% up by HPLC
Molecular formula:C20H32N6O12S2
Molecular weight: 612.63
Description:
Glutathione can occur in reduced (GSH), oxidized (GSSG), or in mixed disulfide forms and is ubiquitous in multiple biological systems serving as the major thiol-disulfide redox buffer of the cell. Glutathione, Oxidized (GSSG) is the oxidized version of the naturally occurring and very important antioxidant glutathione (GSH). In vivo GSSG is reduced back to GSH via the NADPH-dependent enzyme glutathione reductase. The ratio of GSH to GSSG is often used to gauge the level of oxidative stress in cells, with higher concentrations of GSSG implying more oxidative stress, therefore beeing an important bioindicator of cellular health. GSSG functions as a hydrogen acceptor in the enzymatic determination of NADP+ and NADPH and can be a proximal donor in S-glutathionylation post translational modifications. GSSG, along with glutathione and S-nitrosoglutathione (GSNO), have been found to bind to the glutamate recognition site of the NMDA and AMPA receptors (via their γ-glutamyl moieties), and may be endogenous neuromodulators. GSSG can be used as substrate for enzymatically assaying glutathione reductase.
Specification (assay 98% up by HPLC):
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Items
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Standards
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Appearance
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White crystalline powder
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Odor
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Odorless to faint odor
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Identification (IR)
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Pass test
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Identification (HPLC)
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Pass test
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State of solution
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Colorless to yellowish clear
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Specific rotation (at 25℃)
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-103° to -93°
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Heavy metal (As Pb), mg/kg
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≤20
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Moisture, %
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≤6.0
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Residue on ignition, %
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≤0.5
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Ethanol, %
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≤0.05
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Single unknown impurity
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≤1
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Total unknown impurity
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≤2
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Total unknown impurity
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≤4
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Total plate count, cfu/g
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≤100
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Assay, %
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≥98.0
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Production capacity: 1000kg/month
Storage condition: Stored in cool, dry place, room temperature.
Package material: drum
Package size:1kg/drum, 5kg/drum, 10kg/drum, 25kg/drum
