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Product name
|
Latanoprost
|
|
Molecular Formula
|
C26H40O5
|
|
Molecular Weight
|
432.59
|
|
CAS No.
|
130209-82-4
|
|
Quality Standard
|
99% up,
medical grade
|
|
Appearance
|
Light yellow
oil
|
|
TESTS
|
SPECIFICATIONS
|
RESULTS
|
|
Description
|
Colorless or
light yellow oil
|
Light yellow oil
|
|
Identification
|
A: IR
B: The
retention time of the major peak in the chromatogram of the sample
corresponds to that of the standard solution, as obtained in the assay
|
Complies
|
|
Water
|
NMT 2.0%
|
0.05%
|
|
Optical
rotation
|
+31°～+38°
|
+35.2°
|
|
Residue on
ignition
|
NMT 0.5%
|
0.05%
|
|
Related
substances (HPLC)
|
Isopropyl
Dipheny lphosphorylpentanoate
|
NMT0.1%
|
0.06%
|
|
Related
compound B
|
NMT0.5%
|
0.09%
|
|
Related
compound A
|
NMT3.5%
|
N.D
|
|
Any
unspecified impurity
|
NMT0.1%
|
0.06%
|
|
Total other
impurities
|
NMT0.5%
|
0.08%
|
|
Related
Compound E
|
NMT0.2%
|
0.02%
|
|
Residue
Solvent
|
n-Hexane
|
NMT0.029%
|
Not detected
|
|
Ethanol
|
NMT0.5%
|
0.15%
|
|
Methanol
|
NMT0.3%
|
Not detected
|
|
Isopropanol
|
NMT0.5%
|
Not detected
|
|
Assay
|
94.0%~102.0%
|
99.77%
|
|
Conclusion:
The product complies as per above specification.
|
Function of Latanoprost
Latanoprost is a new type of phenyl
substituted prostaglandin F2α, which is a selective F2α receptor agonist. It is
an inactive substance that can quickly penetrate into the cornea and can be
hydrolyzed into active free acids in the cornea and plasma. It can increase the
outflow of aqueous humor through the corneal layer, and the amount of
medication is small, but promotes the outflow of aqueous humor. This product
can also smooth the trabecular meshwork structure of the glaucoma patients that
are usually blocked.
Latanoprost is a new class of ocular hypotensive drugs developed in
recent years and gradually applied to the clinic. Unlike other anti-glaucoma
drugs, this product does not change the flow coefficient of the aqueous humor,
the production of aqueous humor, and suprascleral venous pressure, but reduces
the intraocular pressure by increasing the waterproofing from the uveal scleral
passage and outflow.
