Traditional cough mixtures are formulated around a syrup at 60 - 75% concentration which is made from sucrose, maltodextrin, glucose, invert syrup, etc. The remainder is made up of thickening agents, stabilizers and active ingredients.
The Process
Manufacturers of cough mixtures generally produce their own syrups as this offers greater control of product quality. The manufacturing process must achieve several functions:
-
Dissolving of the sugars to form a syrup
-
Hydration of powdered ingredients
-
Blending ingredients of widely different viscosity
-
Suspension or dissolving of active ingredients
-
The end product must be smooth, agglomerate-free and homogeneous
-
Equipment should conform to GMP standards
The Problem
Using conventional mixers and agitators for this process leads to several potential problems:
-
Conventional agitators cannot dissolve high concentrations of sugars at ambient temperature.
-
Heating of the mixture will be required to aid solution. This is energy inefficient.
-
The cooling process after this further adds to costs and process time.
-
Crystallization of the syrup can occur during heating/cooling.
-
Active ingredients can be damaged by heat.
-
Thickening ingredients will form agglomerates which conventional equipment cannot disperse.
The solution
Bonve offers its homogenizers mixers for Cough Mixtures and Pharmaceutical Syrups Production. It is an efficient type machine with mixing, dispersion, breaking, dissolution, refinery, homogenization and emulsifying. An ideal machine to be instead of colloid mill, ball mill and high pressure homogenizer. The machine can greatly simplify the traditional productions and upgrade the production efficiency and product quality.
WORKING PRINCIPLE
The main parts are stators and rotors. At centrifugal and fluid forces created by rapid turning of the rotors, the stators exercise on the materials with strong power shearing, centrifugal pressing, breaking, fluid friction, turbulent. The processed materials (solid, fluid and gas phase) are quickly refined, homogenized, dis-aggregated and emulsified. The repeat of this process can result in stable and high-quality products.
TECHNICAL PARAMETERS FOR REFERENCE
|
Model
|
Electrical
Power
(Kw)
|
Rotation
Speed
(r/min)
|
Handling
Capacity
(m3/h)
|
Discharge
pressure
(Mpa)
|
Dia. of
inlet/outlet
(mm)
|
|
FHM1/140
|
5.5
|
2900
|
2
|
0.1
|
DN40/32
|
|
FHM1/165
|
7.5
|
2900
|
5
|
0.15
|
DN50/40
|
|
FHM1/185
|
11
|
2900
|
10
|
0.15
|
DN65/50
|
|
FHM1/200
|
15
|
2900
|
15
|
0.15
|
DN80/65
|
|
FHM1/220
|
22
|
2900
|
20
|
0.15
|
DN80/65
|
|
FHM1/240
|
30
|
2900
|
40
|
0.2
|
DN100/80
|
|
FHM1/260
|
37
|
2900
|
60
|
0.2
|
DN125/100
|
|
FHM1/300
|
45
|
2900
|
80
|
0.25
|
DN125/100
|
Above datas are for BONVE single stage inline emulsifying mixer, for a greater shearing and dispersing, three-stage homogenizing mixer can short processing time. Below are the technical parameters.
|
Model
|
Electrical
Power
(Kw)
|
Rotation
Speed
(r/min)
|
Handling
Capacity
(m3/h)
|
Discharge
pressure
(Mpa)
|
Dia. of
inlet/outlet
(mm)
|
|
FHM3/140
|
11
|
2900
|
5
|
0.2
|
DN40/32
|
|
FHM3/165
|
18.5
|
2900
|
10
|
0.3
|
DN50/40
|
|
FHM3/185
|
30
|
2900
|
20
|
0.4
|
DN65/50
|
|
FHM3/200
|
45
|
2900
|
30
|
0.5
|
DN80/65
|
|
FHM3/220
|
55
|
2900
|
40
|
0.5
|
DN80/65
|
|
FHM3/240
|
90
|
2900
|
60
|
0.6
|
DN100/80
|
|
FHM3/260
|
132
|
2900
|
100
|
0.6
|
DN125/100
|
WORKING PROCESSING DIAGRAM
① Homogenizing mixer working with power liquid homogenizing mixer
② Bottom type high shear mixer working with FHM1 Homogenizing mixer
③ Low speed agitator working with FHM3 Homogenizing mixer
④ Multi-pipe FHM3 Homogenizing mixer continuous production process
