|
Product name
|
THYMOPENTIN
|
|
Molecular Formula
|
C30H49N9O9
|
|
Molecular Weight
|
268.93
|
|
CAS No.
|
69558-55-0
|
|
Quality Standard
|
99% up,
medical grade
|
|
Appearance
|
White powder
|
|
Sequence
|
Arg-Lys-Asp-Val-Tyr-NH2
|
|
Character
|
Composed of
arginine, lysine, aspartic acid, tyrosine and valine amino acid
|
|
Test Item
|
Specification
|
Results
|
|
Appearance
|
White to
off-white powder
|
Off-white
powder
|
|
Solubility
|
Very soluble
in water, slightly soluble in ethanol, insoluble in ethyl acetate, ether and
petroleum ether
|
Conform
|
|
Specific
rotation
|
-14.0o ~ -22.0o
|
-16.5o
|
|
Biuret
reaction
|
Should appear
positive reaction
|
Positive
reaction
|
|
IR
|
Infrared
spectrogram should conform to reference substance
|
Conform
|
|
HPLC
|
Retention time
of main peak of test sample should be consistent with reference substance
|
Conform
|
|
pH
|
7.0-9.0
|
8.1
|
|
Water
|
NMT 5.0%
|
2.6%
|
|
Amino acids
|
Arg 0.8-1.2
Asp 0.8-1.2
Lys 0.8-1.2
Tyr 0.8-1.2
Val 0.8-1.2
|
Conform
|
|
Related
substance
|
Single
impurity NMT 1.5%
Total impurity
NMT 2.5%
|
0.2%
0.3%
|
|
Bacterial
endotoxin
|
< 5EU/mg
|
Conform
|
|
Assay
|
97.0% - 103.0%
|
101.1%
|
|
Conclusion
|
It conforms to
the enterprise standard
|
Introduction of Thymopentin 69558-55-0:
Pharmacological effects:
Cell immunoregulatory drugs, can
induce T cell differentiation and promote the development of T lymphocyte
subsets, mature and activation function, and to adjust the proportion of
lymphocyte subsets, it close to normal.
Indications:
Can be used to improve the radiotherapy and chemotherapy for cancer patients immunocompromised result. It can
normalize and prevent all kinds of cellular immune deficiency to some extent
and thus a potential immune modulating agents.
