Dihydroetorphine, a powerful analgesic drug synthesized in the late 1970s, This product is white flake crystal, odorless, sweet taste. Hydrochloride: C25H33NO4·HCl, molecular weight 450.0.
Dihydroetorphine is a pure agonist to the opioid receptors, the affinity to the dark, dark and kappelling receptors is much greater than that to morphine, especially to the dark receptors thousands of times. The dose-effect relationship of its analgesic effect was linear as that of morphine, the equivalent analgesic effect was more than 1000 times stronger than morphine, the duration of efficacy was shorter than morphine, and the respiratory inhibition effect was lighter than morphine. This product also has sedative and antispasmodic effect, can be used for colic caused by smooth muscle spasm, repeated medication can produce drug resistance and dependence, mainly manifested as mental dependence. It has been used for analgesia of various acute and chronic pain.
Indications:
Dihydroetorphine is suitable for analgesia of all kinds of acute and severe pain, such as severe traumatic pain and analgesia of acute and severe pain that is ineffective with morphine and pethidine.
Method of use:
Hypoglossal inclusions, common doses: 20 ~ 40 μg/times, can be repeated 3 ~ 4 hours after the need; The extremes are 60 μg per second, 180 μg per day.
Note: ten to twenty microns per session, two to four hours per session as needed. The extremes are 30 μg per second, 90 μg per day.
Static note: the main anesthesia adjuvant, 0.1 to 0.2 μg /kg/ times, the maximum 0.3 μg /kg.
Endoscopic examination: the preoperative intramuscular injection to 10 μg/times, the maximum to 15 μg/times. Patients were asked to sit or lie down for 30 minutes after surgery.
Use with caution and contraindication:
1. This product is not allowed for those who are allergic to it, pregnant women or lactating women.
See morphine.
3. Patients with cerebral trauma and delirium or insufficiency of lung function are prohibited.
4. Liver and kidney insufficiency should be used with caution.
5. Non-severe pain (such as toothache, headache, rheumatism pain, hemorrhoids pain or local tissue trauma pain, etc.) should not be used.
Adverse reactions:
Can lead to drug dependence (mainly mental dependence); General adverse reactions include dizziness, nausea, vomiting, fatigue, sweating, slow breathing, palpitations, dysuria, speech disorders and urticaria.
Matters needing attention:
This product dependence is big, can contain only when using, cannot swallow the tablet, otherwise affects the analgesic effect. In case of excessive poisoning, artificial respiration should be carried out in time. If necessary, 0.4mg naloxone hydrochloride or 10mg morphine hydrobromate can be given intramuscular injection or intravenous injection. It is stipulated that this product shall not be used as an alternative drug for detoxification treatment of heroin addiction. Shading and airtight preservation.
